The lymphocyte transformation test for the diagnosis of Lyme borreliosis
نویسندگان
چکیده
منابع مشابه
A novel lymphocyte transformation test (LTT-MELISA) for Lyme borreliosis.
Diagnosis of active Lyme borreliosis (LB) remains a challenge in clinically ambiguous, serologically indeterminant, and polymerase chain reaction-negative patients. Lymphocyte transformation tests (LTTs) have been applied to detect specific cellular immune reactivity, but their clinical application has been severely hampered by the poorly defined Borrelia antigens and nonstandardized LTT format...
متن کاملA novel lymphocyte transformation test (LTT-MELISAR) for Lyme borreliosis
Diagnosis of active Lyme borreliosis (LB) remains a challenge in clinically ambiguous, serologically indeterminant, and polymerase chain reaction-negative patients. Lymphocyte transformation tests (LTTs) have been applied to detect specific cellular immune reactivity, but their clinical application has been severely hampered by the poorly defined Borrelia antigens and nonstandardized LTT format...
متن کاملThe lymphocyte transformation test for the diagnosis of Lyme borreliosis has currently not been shown to be clinically useful.
I would like to comment on the letter from Dessau et al.: “Lymphocyte transformation test for diagnosis of Lyme borreliosis is currently not documented to be clinically useful” [1]. I wish to thank Dessau and colleagues for their interest in our study and am very pleased that they confirm that the lymphocyte transformation test (LTT) shows a high specificity in seronegative cases [1]. Especiall...
متن کاملThe Lymphocyte Transformation Test for Borrelia Detects Active Lyme Borreliosis and Verifies Effective Antibiotic Treatment
Borrelia-specific antibodies are not detectable until several weeks after infection and even if they are present, they are no proof of an active infection. Since the sensitivity of culture and PCR for the diagnosis or exclusion of borreliosis is too low, a method is required that detects an active Borrelia infection as early as possible. For this purpose, a lymphocyte transformation test (LTT) ...
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ژورنال
عنوان ژورنال: Clinical Microbiology and Infection
سال: 2015
ISSN: 1198-743X
DOI: 10.1016/j.cmi.2014.10.001